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Dr. Clay Siegall is living legend of targeted cancer therapies

Today, it is largely taken for granted that if someone develops cancer, there’s a very good chance they’ll be able to survive, with a high degree of certainty, at the five-year survival benchmark. This is largely due to advancements that have taken place over the last 70 years. The advent of both radiation treatment and chemotherapy mark the beginning of modern cancer treatment, with real improvements in survivability seen across a wide swath of cancer types.

But in the mid-1980s, these advancements had become stagnant. Many types of cancers were no longer seeing the momentous gains and survivability that had been a staple of the ‘30s through the ‘60s. The cancer treatment industry needed to find new inroads to improving survivability.

Another aspect of the old treatment regimen was the sheer brutality of the side effects. The mainstays of cancer treatment had long been excision, radical surgery and both radiation and chemotherapy. All of these treatment modes had severe side effects associated with them. For example, people undergoing chemotherapy often times end up with permanent paresthesia, sensory deficits and other neurological conditions, including severe dementia. While not all patients experience these side effects at a high degree, they are bad enough that they represent a serious obstacle to the return to total health of the patient.

Beginning in the mid-‘90s, a man by the name of Clay Siegall became interested in a new field of cancer research called targeted cancer therapies. As a senior researcher at Bristol-Myers Squibb, Dr. Siegall first started working on a new class of targeted drugs called antibody drug conjugates. Antibody drug conjugates use the immune system to create antibodies, which are bound to cytotoxic agents. The major benefit of this method of cancer treatment is that there is no systemic release of the cytotoxic agents into the bloodstream, dramatically increasing the therapeutic window and allowing for highly lethal doses to be delivered directly to the site of the tumor. Whereas traditional chemotherapy may have taken six courses to reduce the tumor size by 25 percent, antibody drug conjugates can reduce the tumor size to nothing in just one treatment. And they have minimal associated side effects.

How Nick Vertucci Channels His Early Childhood Difficulties Into Success

Nick Vertucci is the founder and chief executive officer of NV Real Estate Academy. The firm offers customers with a wide variety of knowledge and assets useful in the real estate business and career. He employs similar tactics that he used to scale up the industry in training models and career advisory. Through his firm, hundreds of people have realized success in real estate, magnified their incomes and revolutionized their personal lives.

Nick Vertucci’s successful platform was built brick by brick from his early life of hardship. He was born into a comfortable American family with middle-sized revenues. At age nine, his father passed away leaving his mother to fend for the family. She compensated for the lost income by working extra-long hours to sustain Nick and his siblings. At eighteen years old, Nick had begun his independent journey in life and was living out of his van with minimal cash. He worked odd jobs to survive time after time until he set up a computers’ sales shop. The money afforded him a more comfortable lifestyle that allowed him to start a family. In the 2000s, his business took a hit from the rapidly rising dot-com era. Nick Vertucci attributes the reversal of his success to a lack of foresight in the technological field and investments reported on

This unprecedented crash affected his income and savings, throwing him deep into debt which almost took away his home. It was during this tumultuous times that Nick Vertucci accompanied his pal to attend a real estate training seminar and recalls that it was the best decision of his life. He sat through the forum absorbing perceptions and information of the industry, even the ones that were unclear to him. After a decade of plowing his way through the niche, Nick Vertucci is a testament to what the right information, endurance, and good mentorship can do to a failing situation. He has a millionaire tag free of debt and plentiful of a bountiful family legacy.

Nick’s firm offers clients with the know-how of purchasing, rehabilitating and reselling a property at a benefit. He believes that it is possible to become one’s boss with the support of NV Real Estate Academy on Other services available through the firm include asset protection, commercial investments, leveraging of 401K and IRA, timing the most convenient time to resell property and wholesaling assets. Nick Vertucci has a team of equally passionate professionals with an undeterred goal to deliver a simplified method for success in real estate at

End Citizens United On Upward Trajectory

End Citizens United, or ECU, has been around since 2015 working hard to fight back against the United States Supreme Court decision that laid a precarious premise that corporations are people. Since its inception the political action committee has had many battles, and now in 2017 the Trump election has its own fair share of fuel for the fire. The organization is quite worried about the recent Times press release which confirms that Russia paid for digital ads to help influence the election towards a candidate of its favor.


Tiffany Muller is the president and executive director at End Citizens United and she specifically stated that it just underscores how vulnerable the election process is given the flimsy campaign laws. It is precisely these laws that the PAC has been working to dismantle, but unfortunately not enough progress has been made as emphasized by the latest press releases. There are so many loopholes that are simply so huge that those who would use them to undermine the United States election process by giving millions and anonymously at that simply cannot be tracked. Now is the time, she says, to join in with the cause to reform the laws before there is no chance left at all.


So far the PAC of End Citizens United has raised a significant amount of money of their own to help fight against the injustices that they see everywhere in the past year’s election cycle. Already there has been $4 million raised with the projection that this will be an even more sizable figure, $35 million, in time for the midterm elections which could possibly be one of the final chances to make a difference before the nation sinks to far into the corporate agendas and business wishlists that have kept true freedom from settling in.


This, if it turns out to be true, would certainly be an improvement over the $25 million which was gathered for their first election cycle in operation that was 2016. The number of donors is up to about 100,000 out of which only 40,000 of them are repeat donors which shows that End Citizens United is certainly making their name known to others with similar mindsets and causes close to their hearts. If the numbers continue on such an upward trajectory then it may be close time for those corporations who have gotten away with so much for so long to watch out.


Why Timothy Armour Should Be Noted As Being a Great Investment Analyst

Timothy D. Armour is well known for being both the chairman and chief executive officer of an organization called the Capital Group. He is also known for being the chairman and principal executive officer of Capital Research and Management Company, Inc. which is currently a part of the Capital Group as well. He is currently assuming the position of an equity portfolio manager in which he is helping clients with building, maintaining, and diversifying their investments.

Tim currently possesses 34 years of experience with investments, all of which have been with the Capital Group. In the earlier days of his career, as an equity investment analyst of The Capital Group, he covered both global telecom and U.S. service companies. Tim had begun his career at The Capital Group as participant of The Associates Program. He is currently holding a bachelor’s degree in the subject of economics and is based in the city of Los Angeles, CA.When it comes to the world of investments, there are no doubts about the fact that Mr. Warren Buffett is a well known figure. He has been known for wagering $1,000,000 for charity in which he can achieve better returns on investment than a group of managers of hedge funds.

All he has to do is invest in an S&P 500 passive index fund. That particular bet is going to be decided in this very year. It is also looking like Mr. Buffett is going to have a great time collecting that amount.Mr. Buffett has been correct in the sense that there are many expensive and mediocre funds that have had impacts of shortchanging investors. He has made a commitment to simple investments with low cost, all of which should be held after purchasing for longer terms. Be sure to speak with an investment analyst who will be able to provide you with assistance in investing today.


Wild Ark delivers “eco-tainment” for everyone!

Everyone needs a vacation now and then, but for the environmentally conscious traveler, it isn’t enough to simply find some new place to be a consumer. They might be looking for something that provides a degree of personal enrichment, or even a chance to make a difference. That’s where a company like Wild Ark comes in.


Wild Ark isn’t just some travel agency. It was founded by actual conservationists who share a passion for protecting the biodiversity found across the globe, and they are dedicated to taking people on journeys of ecological edutainment! Wild ark offers eco-conscious opportunities for rest and relaxation as well as full on courses for the aspiring naturalist.


One of the more relaxing travel destinations that Wild Ark offers is the “Alaska Sportsman’s Lodge”. With no set schedule, you are given unlimited time for guided fly fishing over the course of two and a half days, four and a half days, or even a full week. There’s no need to worry about what kind of gear to pack. Everything is provided, including fishing equipment, fishing guides, accommodations, and even meals. Whether you are a novice to fly fishing, or a seasoned veteran, you are sure to enjoy this memorable experience on the Kvichak River.


If you are looking for a more intense learning experience, then you might want to try Wild Ark’s “EcoTracker” course. This trip is actually administered by an organization called “EcoTraining”. They are Wild Ark’s training partner. “EcoTracker” is all about learning the skills required for tracking animals in the wild, and it provides real hands on experience in South Africa and Botswana. This particular course is offered in both 7 day, and 14 day options.


Wild Ark offers up a variety of unique travel destinations, and every expedition contributes to the conservation of the ecosystem being visited. They are an ideal choice when it comes to the travel needs of those individuals for whom an eco-conscious adventure beckons!


Visit for more information.

Julia Jackson Leads the Expansion of Jackson Family Wines to Sonoma County

Julia Jackson is the youngest daughter of Jess Jackson, the founder of Jackson Family Wines. In an interview, Julia describes how she remembers picking and sorting grapes at a tender age. The family had done business in the wine industry before she was born. However, Julia Jackson has diverted from the wine industry by joining Cambria Estates as a spokesperson. Cambria Estate Winery is a non-profit organization that seeks to empower women. On November 2014, the institution pledged $ 100, 000 annually to empower and celebrate exceptional women in the society. The non-profit organization got founded by Cambria Proprietors, Katherine, and Julia Jackson. The seeds of empowerment program seek to honor what Julia calls Warrior Women. The program intends to provide financial support to organizations dedicated to the development of women.

Through the institution, Julia Jackson and her team work locally and internationally to identify, train and empower women who are instrumental in changing their communities. For over 30 years, the fund has dedicated itself to strengthening the role of women in the society through grassroots projects. During her early years, Julia made friendship with a French speaking daughter of a winemaker employed in their firm. As a result, she studied French during summer and on several occasions, she enrolled as a French teacher during her time in college. Julia graduated with a BA from Scripps College and attained a certificate in general management from Stanford Graduate School of Business.

On 6th October 2015, Jackson Family Wines launched the company’s flagship Sonoma County wine. According to Julia, Sonoma has a reputation of loving the Pinot Noir and Chardonnay. However, she believed the best wine for the place was the Cabernet. Julia also pointed out that the reason Sonoma County was less famous as considered to counties like Napa was due to lack of marketing resources. However, it was the company intentions to ensure the county received recognition in the wine industry. Additionally, a wine called Acaibo from Trinite Estate Winery is setting root in the county.

Bruce Bent II Culminated Success and Financial Management

Bruce Bent II continues to be one of the leading financial managers with his continued success leading some of the largest companies. At the helm of Hallmark and Double Rock, Bent II has spearheaded some of the most successful financial management businesses in all of New York. His success is partially in part do to the legacy and skills given to him by his father. The success in the Bent family has culminated from his father’s success in creating the country’s first money market in 1970. This feat was incredibly remarkable and would ultimately help propel Bent II towards success in the monetary sector.

Rise to Success
Rising to success in the economic sector is not as easy as applying for a job. Bent II’s path to success came in the form of his father. His father took it upon himself to teach Bruce Bent II every tip needed in order to become extremely successful in the financial sector. Fund management involves many legalities that it takes a keen mind to handle. Having an in and out knowledge has allowed Bruce Bent II to be able to successfully orchestrate one of the best business operations in the money market with Double Rock. Before starting his career, Bent II earned his bachelor’s in economics at Northeastern University.

Double Rock and Bruce Bent II
Double Rock has continued to permeate Bruce Bent II’s career. Bent II has been with the company his entire business career. This longevity has allowed him to craft the perfect set of skills needed to be capable to lead the company into continued fiscal success. Bruce Bent II learned the skills that are necessary to be capable to succeed long term financial career. His time with Double Rock was some of his most important work escalating him to success. Currently he is the vice chairman and president of Double Rock.

Bruce Bent II’s continued success comes from a combination of his father’s success and from his developed skills whilst working at Double Rock. These combined have allowed Bruce Bent II to earn a position in the business world that defines who he is as a businessman and wealthy individual. His success has carved out a path towards more financial management success.

For more information on Bruce Bent II follow him on Twitter.

Get Your Car Ready for Your Summer Road Trip

Before you and your friends or family head out for your summertime road trip, it’s important to make sure your car is in great condition. Here are a few tips to ensure that your vehicle will get you where you want to go safely.


First, check your tires. Use a pressure gauge to make sure there is adequate air in your tires and add more air as needed. It’s also a good idea to have your mechanic take a look at the tires to see if you should have your tires rotated or replaced before getting on the road.


It’s also imperative that you check the fluids in your vehicle. The summer weather can negatively affect your engine, so make sure there is enough antifreeze in the car, and use a thicker grade of oil to ensure that the engine is properly lubricated. You should also fill up the windshield wiper fluid in the car to ensure that you can safely drive through the rain on your road trip.


An overall tuneup is also recommended to keep your car running smoothly as you embark on new adventures this summer.

Find more information for used cars, including luxury vehicles like BMWs at Beverly Hills Auto Group in Queens.

Rona Borre is The Model Business Woman

In 2001, Rona Borre started her new company, Instant Alliance, a Chicago staffing and recruiting company. She had just quit a high-paying job where she had beaten every sales record the company had ever recorded because she figured that she had reached the limit to what she could accomplish there. Go here at


Today, Borre is the founder and CEO of one of the fastest-growing companies in the United States. Instant Alliance bills out millions of dollars to clients annually and provides new hires to Fortune 500 companies, companies that are mid-sized, and even small companies. Borre specializes in the hiring of technological and financial professionals because these are the folks that a company needs when growing to the next level, and they are always in demand. Explore more.


Borre learned early in the staffing business that it paid to be unique and use techniques that work as opposed to techniques that everyone else used. Many of her competitors still shuffle through endless amounts of resumes, hoping to find the one or two that fit what a client wants in the way of an employee.


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Instead, Borre and her associates spend a great deal of time and effort getting to know the executives of the recruiting division. Hop on to read more.

Fabletics: Taking over the Fashion e-Commerce Industry

Fabletics has managed to do in three years, what most companies take years to achieve; conquering Amazon. For a long time, Amazon has been controlling 20% of the market. This has made it very hard for the different online retail store to succeed.


Through their technique, Fabletics has raised$250 million in revenue in the last three years.


How is Fabletics winning?


Kate Hudson and her partners decided to launch a brand that is different from the rest. They established a member-based Company. It is this is a simple idea that has made Fabletics a household name. All their customers sign up, and the management team request on their fashion preference.


The strategies used


One can’t plan to compete with Amazon without having strategies and a plan. This is something that Fabletics understand, and that is why they have developed simple yet robust strategies. The most important strategy they have incorporated in reverse showrooming.


Showrooming is a process that has made most businesses to fall. It is a technique used by buyers to gain more information on a product. They will visit the different online store, collect information and buy the clothes from other stores at a discount.


Fabletics opened pop-up stores that their clients can use to access the different clothes. Retail is another channel of building clientele, and the Company has maximized on the idea. In fact, 25% of the new customers become members at the stores.


Maximizing on the data


It is important for the retail stores to display what the clients want to see. That is why Fabletics uses the data on the clients’ preferences to stock the stores. All the products displayed are appealing to the customers.


About Fabletics


Fabletics is an online retail store that manufactures activewear for women. Kate Hudson is the co-founder and the face of the Company. Using her celebrity status, she has managed to increase the popularity of the brand.


How it works


All members of the Company are required to sign up. You will be asked to fill in a form indicating your fashion preference. If you don’t know what you prefer, you are advised to take the Lifestyle Quiz and determine the gear suitable for you.


Once you become a member, you will receive an email every month with the fashion trend of that month. You don’t have to buy the clothing. However, you will be required to make a decision if you are going to buy or not. Failure to make a decision by 5th of that month will result in a store credit of $49.


Fabletics launched a male activewear in 2015. Soon after, they included dresses and shoe brands.


The style and quality


The gym wear is made of high-quality material. They are also quite affordable for the average Americans. The Company has a broad range of styles that you can choose from. Most of the bottoms are designed with solid colors. However, you can also find pants with bold patterns.